Peripheral giant cell granuloma (PGCG) is a relatively common benign reactive lesion of the oral cavity which can occur at any age.\nCTCFL/BORIS (CTCF like/Brother of the Regulator of Imprinted Sites) and CTCF (CCCTC-binding factor) are paralogous genes\nwith an important role in the regulation of gene expression, genomic imprinting, and nuclear chromatin insulators regulation.\nBORIS expression promotes cell immortalization and growth while CTCF has tumor suppressor activity; the expression pattern\nmay reflect the reverse transcription silencing of BORIS.The aim of this work was to describe a histopathological and molecular\napproach of an 8-year-old pediatric male patientwith PGCGdiagnosis. It was observed that the PGCGunder study expressed CTCF\nas well as BORIS mRNAs alongside with the housekeeping gene GAPDH, which may be related to possible genetic and epigenetic\nchanges in normal cells of oral cavity.
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